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KMID : 0363020050350020335
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Journal of Korean Academy of Periodontology
2005 Volume.35 No. 2 p.335 ~ p.343
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A study on the safety and efficacy of bovine bone-derived bone graft material(OCS-B)
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박호남
한상혁/김경화/이상철/박윤정/이상훈/김태일/설양조/구영/류인철/한수부/정종평
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Abstract
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Inorganic bovine bone mineral has been widely researched as bone substitution materials in
orthopedic and oral and maxillofacial application. OCS-B(NIBEC, Korea) is newly-developed
inorganic bovine bone mineral. The aim of this study is to evaluate the safety and efficacy of
bovine bone-derived bone graft material(OCS-B).
Micro-structure of newly-developed inorganic bovine bone mineral(OCS-B) was analyzed by
scanning electron microscope(SEM). Round cranial defects with eight mm diameter were made
and filled with OCS-B in rabbits. OCS-B was inserted into femoral quadrant muscle in mouse.
In scanning electron microscope, OCS-B was equal to natural hydroxyapatite. Rabbits were
sacrificed at 2 weeks and 4 weeks after surgery and mice were sacrificed at 1 week and 2
weeks after surgery. Decalcified specimens were prepared and observed by microscope. In calvarial defects, osteoid and new bone were formed in the neighborhood of OCS-B at 2 weeks after surgery. And at 4 weeks after surgery osteoid and new bone bridge formed flourishingly.
No inflammatory cells were seen on the surface of OCS-B at 1 week and 2 weeks in mouse experimental group.
It is concluded that newly-developed inorganic bovine bone mineral(OCS-B) is a flourishing
bone-forming material and biocompatible material.
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KEYWORD
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bovine bone, bone regeneration, calvarial defect
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